DRUM
TO HOPPER CONCEPT:
We
offer ready pellets as single or in combination blends for filling
into hard gelatin capsules at your factory.
CONTRACT
MANUFACTURING FACILITIES:
We
offer complete finished pack formulations of pellets in capsules
and SR tablets, in blister and strip packing, for your local
and international marketing.
YOUR EXTENDED R&D ARM:
You
can share your existing molecule or new molecule/product combo
to be developed as pellets, and we shall develop the product for
you.
| ADVANTAGES
OF PELLETIZATION: |
Different
types of pellets can be coated with different drugs and release
profiles.
The
pellet form provides a smoother absorption profile from the GI
TRACT.
IMMEDIATE
RELEASE PRODUCTS show better bioavailability since pellets
are spread throughout the GI tract.
Chemically
incompatible products can be pelletized in separate pellets and
then blended to encapsulate in hard gelatin capsules.
Avoids
dust formation associated with tablet granulations during processing.
Improved
aesthetic appeal of the product.
Launch
existing products as line extensions in new dosage form.
| EXTRUSION
- SPHERONIZATION: |
CAN
IMPROVE YOUR PRODUCTS PERFORMANCE
•
Producing a smooth particle surface suitable for thin layer coating
• Forming granules with a specific bio-consumable shape.
• Conditioning particles to prevent generation of dust and
fines
• Increasing flowability by elimination of sticking or bridging
points.
• Increasing the apparent bulk density up to 25% compared.
top
| COMPARISION
BETWEEN CONVENTIONAL COATING PAN TECHNOLOGY VS EXTRUSION SPHERONIZATION: |
| Conventional
Technology (Coating Pan) |
Extrusion
& Spher'oidisation |
| Labor
dependant |
Automised |
| Minimum
Cycle - 6-12 hrs. (35kg load) |
Minimum
Cycle-0.5- 1.5hrs |
| Lot
to lot variation |
Consistency
upto 96% |
| Solvents
required are high |
Solvent
requirement is low |
| Conventional
Technology (Coating Pan) |
Extrusion
& Spher'oidisation |
| Sugar
content is high in the formulation |
Practically
no sugar content in the beadlets |
| Sugar
pellets take up moisture even in low humidity and show
colour leaching in blister strips on keeping |
Stability
of formulation is improved since it has very low moisture
uptake in high humidity. |
top
